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PTSD Clinical Trials Recruiting in the US

260 studies for PTSD are recruiting at 457 US sites, according to ClinicalTrials.gov data processed .

Post-traumatic stress disorder (PTSD) is a mental health condition that can develop after experiencing or witnessing a traumatic event.

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Top PTSD studies by number of US sites

Showing 30 studies, most US recruiting sites first.
  1. An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

    NCT07456696

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    37 US recruiting sites
  2. ERP to Improve Functioning in Veterans With OCD

    NCT05240924

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    19 US recruiting sites
  3. Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers

    NCT05457985

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    12 US recruiting sites
  4. Reducing Posttraumatic Stress Disorder (PTSD) Symptoms in First Responders and Frontline Health Care Workers

    NCT05751473

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    10 US recruiting sites
  5. Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)

    NCT06636786

    • Phase 2
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    8 US recruiting sites
  6. Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder

    NCT07570654

    • Phase 2/3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    7 US recruiting sites
  7. Massed Prolonged Exposure for PTSD in Substance Use Treatment

    NCT06296186

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    6 US recruiting sites
  8. A Study of a Novel EEG Neurofeedback System for PTSD Treatment

    NCT06770998

    • Interventional
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    6 US recruiting sites
  9. CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

    NCT05663034

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    5 US recruiting sites
  10. Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons

    NCT06923423

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    5 US recruiting sites
  11. Integrated Health Care for PTSD

    NCT07220681

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    5 US recruiting sites
  12. Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

    NCT07226232

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    5 US recruiting sites
  13. Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress

    NCT03642028

    • Phase 4
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  14. The ED-AWARENESS-2 Trial

    NCT05534243

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  15. Evaluating Treatments for Suicidal Veterans With PTSD

    NCT05974631

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  16. Trauma-Informed Guilt Reduction Therapy Compared to Prolonged Exposure

    NCT06296589

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  17. Promoting Improved Functioning Among People Experiencing Stressful Situations

    NCT06482567

    • Interventional
    • Ages 18 to 50 years
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  18. Improving Behavioral Health for Caregivers and Children After Pediatric Injury

    NCT06856057

    • Interventional
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    4 US recruiting sites
  19. Reducing Dropout and Improving Outcomes From PTSD Therapy: When to Switch Therapies or Stay the Course

    NCT06957067

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  20. SMART Therapist Training: A Hybrid Factorial-SMART Design

    NCT07010770

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  21. Cervical Plexus Hydrodissection With D5W Versus NS for Treatment-Resistant PTSD

    NCT07382596

    • Phase 4
    • Ages 19 to 90 years
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  22. Non-invasive Nerve Stimulation for PTSD and Sleep

    NCT03170440

    • Interventional
    • Ages 18 to 55 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    3 US recruiting sites
  23. Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD

    NCT03932773

    • Interventional
    • Ages 18 to 60 years
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  24. An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample

    NCT04180930

    • Observational
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    3 US recruiting sites
  25. Family Involvement in Treatment for PTSD (FIT-PTSD): A Brief, Feasible Method for Enhancing Outcomes, Retention, and Engagement

    NCT05267665

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  26. Methylphenidate for the Treatment of PTSD With Associated Neurocognitive Complaints

    NCT05776056

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  27. Positive Processes and Transition to Health (PATH)

    NCT06093906

    • Interventional
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  28. Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

    NCT06162741

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  29. Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

    NCT06210711

    • Interventional
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  30. Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

    NCT06262178

    • Interventional
    • Ages 18 years and older
    • Sex: Female
    Recruiting sites
    3 US recruiting sites

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FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a PTSD clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.