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Schizophrenia Clinical Trials Recruiting in the US

115 studies for Schizophrenia are recruiting at 621 US sites, according to ClinicalTrials.gov data processed .

Schizophrenia is a serious mental health condition that affects how a person thinks, feels and perceives reality.

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Recruiting now

Top Schizophrenia studies by number of US sites

Showing 30 studies, most US recruiting sites first.
  1. Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

    NCT06229210

    • Phase 3
    • Ages 5 to 17 years
    • Sex: All
    Recruiting sites
    47 US recruiting sites
  2. NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

    NCT07114874

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    47 US recruiting sites
  3. A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

    NCT07459647

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    45 US recruiting sites
  4. A Study of Brenipatide in Adult Participants With Schizophrenia

    NCT07410507

    • Phase 2
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    32 US recruiting sites
  5. 52-week Open Label Safety-Tolerability Study

    NCT07369154

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    23 US recruiting sites
  6. Randomized Withdrawal Study in Patients With Schizophrenia

    NCT06961968

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    22 US recruiting sites
  7. NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

    NCT06963034

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    21 US recruiting sites
  8. Efficacy of NBI-1117568 in Preventing Relapse in Adults With Schizophrenia

    NCT07227818

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    20 US recruiting sites
  9. A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

    NCT07105111

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    19 US recruiting sites
  10. Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)

    NCT07379827

    • Observational
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    19 US recruiting sites
  11. Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

    NCT05184335

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    18 US recruiting sites
  12. Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder

    NCT05303064

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All
    Recruiting sites
    15 US recruiting sites
  13. Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

    NCT07101094

    • Observational
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    14 US recruiting sites
  14. A Study to Evaluate KYN-5356 in Adults With Cognitive Impairment Associated With Schizophrenia

    NCT07191483

    • Phase 2
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    14 US recruiting sites
  15. Study of ALTO-101 in Patients With Schizophrenia

    NCT06502964

    • Phase 2
    • Ages 21 to 55 years
    • Sex: All
    Recruiting sites
    13 US recruiting sites
  16. A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

    NCT07288567

    • Phase 3
    • Ages 13 to 17 years
    • Sex: All
    Recruiting sites
    13 US recruiting sites
  17. Study to Evaluate LB-102 for the Treatment of Adult Patients With Acute Schizophrenia

    NCT07363577

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    13 US recruiting sites
  18. A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents

    NCT07424404

    • Phase 3
    • Ages 5 to 17 years
    • Sex: All
    Recruiting sites
    13 US recruiting sites
  19. Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medications

    NCT07565428

    • Phase 3
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    13 US recruiting sites
  20. A Study to Evaluate the Effect of KarXT on Urological Safety

    NCT07221877

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    12 US recruiting sites
  21. Safety and Tolerability of Open-Labeled Iloperidone in Adolescents

    NCT05648591

    • Phase 4
    • Ages 12 to 17 years
    • Sex: All
    Recruiting sites
    11 US recruiting sites
  22. A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia

    NCT07734493

    • Phase 1
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    10 US recruiting sites
  23. A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT

    NCT07061288

    • Phase 1
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    8 US recruiting sites
  24. A Study of the Feasibility, Safety and Tolerability of Aticaprant as Adjunctive Treatment in Participants With Schizophrenia

    NCT07615426

    • Phase 1
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    8 US recruiting sites
  25. Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

    NCT05208190

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    7 US recruiting sites
  26. A Study to Assess Adverse Events, Change in Disease Activity, and How Oral Emraclidine Moves Through the Body in Adult Participants With Schizophrenia

    NCT07145918

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    7 US recruiting sites
  27. Study to Assess the Safety, Tolerability, and Treatment Response of GXV813 in Hospitalized Adults With Schizophrenia

    NCT07467993

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    7 US recruiting sites
  28. Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia

    NCT07686263

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    7 US recruiting sites
  29. Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

    NCT06740383

    • Observational
    • Ages 18 to 40 years
    • Sex: All
    Recruiting sites
    6 US recruiting sites
  30. NBI-1117568-SCZ3030: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

    NCT07105098

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    6 US recruiting sites

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Schizophrenia clinical trials by city

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Schizophrenia clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.