Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)
NCT05987852
This study is recruiting at 12 US sites in 10 states, according to its ClinicalTrials.gov record last updated .
Summary
Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric pressure to increase tissue oxygenation. Two small prospective randomized controlled trials have demonstrated that the delivery of HBOT to UC patients hospitalized for acute moderate to severe flares results in improved remission rates and avoidance of in-hospital progression to biologics, small molecules, or colectomy.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Ulcerative Colitis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Not applicable
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Northwestern University
- Last updated on ClinicalTrials.gov
- January 8, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama Medicine · Birmingham, AL
California · 1
- University of Los Angeles Health · Los Angeles, CA
Florida · 2
- University of Miami Health · Miami, FL
- Orlando Health · Orlando, FL
Illinois · 1
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
Kentucky · 1
- University of Louisville · Louisville, KY
Massachusetts · 1
- Massachusetts General Hospital · Boston, MA
Minnesota · 1
- Mayo Clinic · Rochester, MN
New Hampshire · 1
- Dartmouth Hitchcock Medical Center · Lebanon, NH
New York · 1
- State University of New York Upstate Medical University · Syracuse, NY
Pennsylvania · 2
- Allegheny Health · Pittsburgh, PA
- University of Pittsburgh Medical Center · Pittsburgh, PA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.