Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.
NCT06846281
This study is recruiting at 43 US sites in 23 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this Phase 3b study is to assess the efficacy, safety and tolerability of remibrutinib after switching from ocrelizumab and compared to continuous ocrelizumab treatment, in patients living with relapsing multiple sclerosis (plwRMS).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Relapsing Multiple Sclerosis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 40 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Novartis Pharmaceuticals
- Last updated on ClinicalTrials.gov
- August 26, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Perseverance Research Center · Scottsdale, AZ
California · 1
- University of California Irvine · Irvine, CA
District of Columbia · 1
- Medstar Washington Hospital Center · Washington D.C., DC
Florida · 11
- Neurology of Central FL Res Ctr · Altamonte Springs, FL
- University of Florida · Gainesville, FL
- Memorial Healthcare System · Hollywood, FL
- Neurology Associates PA · Maitland, FL
- Elite Clinical Research · Miami, FL
- Aqualane Clinical Research · Naples, FL
- Advent Health Orlando · Orlando, FL
- Orlando Health Clinical Trials · Orlando, FL
- Tallahassee Neurological Clinic · Tallahassee, FL
- University Of South Florida · Tampa, FL
- Vero Beach Neurology · Vero Beach, FL
Illinois · 2
- Rush University Medical Center · Chicago, IL
- University of Chicago · Chicago, IL
Kansas · 1
- University of Kansas Hospital · Kansas City, KS
Maryland · 1
- MedStar Montgomery Medical Center · Olney, MD
Massachusetts · 2
- Lahey Hospital and Medical Center · Burlington, MA
- Neurology Center of New England PC · Foxborough, MA
Michigan · 2
- Michigan Institute of Neurological · Farmington Hills, MI
- Memorial HC Ins for Neuroscience · Owosso, MI
Missouri · 1
- WA Uni School Of Med · St Louis, MO
Nevada · 1
- Cleveland Clinic Foundation · Las Vegas, NV
New Jersey · 1
- Holy Name Medical Center · Teaneck, NJ
New Mexico · 1
- University of New Mexico · Albuquerque, NM
New York · 1
- SUNY Buffalo The Jacobs Neuro Inst · Buffalo, NY
North Carolina · 1
- Velocity Clinical Research · Raleigh, NC
North Dakota · 1
- Sanford Health · Fargo, ND
Ohio · 4
- Premier Health · Centerville, OH
- Univ of Cincinnati Medical Center · Cincinnati, OH
- Cleveland Clinic Foundation · Cleveland, OH
- Ohio Health Research Institute · Columbus, OH
Oregon · 1
- Providence Neurological Services West · Portland, OR
South Carolina · 1
- Premier Neurology · Greenville, SC
Tennessee · 1
- Sibyl Wray MD Neurology PC · Knoxville, TN
Texas · 4
- Austin Regional Clinic · Austin, TX
- Univ of Texas Southwest Med Center · Dallas, TX
- John Peter Smith Hospital · Fort Worth, TX
- Saturn Research Solutions LLC · Plano, TX
Virginia · 1
- Virginia Commonwealth University · Richmond, VA
Wisconsin · 2
- Center for Neurological Disorders G · Greenfield, WI
- Medical College of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.